Bağırsak Mikrobiyotası ve Tip 2 Diyabetes Mellitus

World Health Organization (2016, 24 Mayıs) Global Reports on Diabetes. World Health Organization. WHO Press, Geneva. https://www.who.int/publications/i/item/9789241565257

International Diabetes Federation (2017, 30 Nisan) Diabetes Atlas. Eighth Edition. https://diabetesatlas.org

Lyssenko, V., Jonsson, A., Almgren, P., Pulizzi, N., Isomaa, B., Tuomi, T., Berglund, G., Altshuler, D., Nilsson, P., & Groop, L. (2008). Clinical risk factors, DNA variants, and the development of type 2 diabetes. TheNew England Journa of Medicine, 359, 2220–2232. https://doi.org/10.1056/ NEJMoa0801869

Everard, A., & Cani, P.D. (2013). Diabetes, obesity and gut microbiota. Best practice & research Clinical Gastroenterology, 27(1), 73-83. https://doi.org/10.1016/j.bpg.2013.03.007.

Kahn, S.E., Hull, R.L., & Utzschneider, K.M. (2006). Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature, 444, 840–846. https://doi.org/10.1038/nature05482.

Zhang, L., Chu, J., Hao, W., Zhang, J., Li, H., Yang, C., & Wang, H. (2021). Gut microbiota and type 2 diabetes mellitus: Association, mechanism, and translational applications. Mediators of Inflammation, 2021. https://doi.org/10.1155/2021/5110276.

Gomaa, E. Z. (2020). Human gut microbiota/microbiome in health and diseases: a review. Antonie Van Leeuwenhoek, 113(12), 2019-2040. https://doi.org/10.1007/s10482-020-01474-7.

Bielka, W., Przezak, A., & Pawlik, A. (2022). The role of the gut microbiota in the pathogenesis of diabetes. International Journal of Molecular Sciences, 23(1), 480. https://doi.org/10.3390/ijms23010480.

Salgaço, M. K., Oliveira, L. G. S., Costa, G. N., Bianchi, F., & Sivieri, K. (2019). Relationship between gut microbiota, probiotics, and type 2 diabetes mellitus. Applied Microbiology and Biotechnology, 103, 9229-9238. https://doi.org/10.1007/s002253-019-10156-y.

Trøseid, M., Nestvold, T. K., Rudi, K., Thoresen, H., Nielsen, E. W., & Lappegård, K. T. (2013). Plasma lipopolysaccharide is closely associated with glycemic control and abdominal obesity: evidence from bariatric surgery. Diabetes Care, 36(11), 3627-3632. https://doi.org/10.2337/dc13-0451.

Sircana, A., Framarin, L., Leone, N., Berrutti, M., Castellino, F., Parente, R., & Musso, G. (2018). Altered gut microbiota in type 2 diabetes: just a coincidence?. Current Diabetes Reports, 18, 1-11. https://doi.org/10.1007/s11892-018-1057-6.

Kuzu, F. (2017). Bağırsak mikrobiyotasının obezite, insülin direnci ve diyabetteki rolü. Journal of Biotechnology and Strategic Health Research, 1, 68-80. htthttps://dergipark.org.tr/en/pub/bshr/issue/32641/363323

Cunningham, A. L., Stephens, J. W., & Harris, D. A. (2021). Gut microbiota influence in type 2 diabetes mellitus (T2DM). Gut Pathogens, 13(1), 1-13. https://doi.org/10.1186/s13099-021-00446-0.

Portincasa, P., Bonfrate, L., Vacca, M., De Angelis, M., Farella, I., Lanza, E., & Di Ciaula, A. (2022). Gut microbiota and short chain fatty acids: implications in glucose homeostasis. International Journal of Molecular Sciences, 23(3), 1105. https://doi.org/10.3390/ijms23031105.

Al Bander, Z., Nitert, M. D., Mousa, A., & Naderpoor, N. (2020). The gut microbiota and inflammation: an overview. International Journal of Environmental Research and Public Health, 17(20), 7618. https://doi.org/10.3390/ijerph17207618.

Adak, A., & Khan, M. R. (2019). An insight into gut microbiota and its functionalities. Cellular and Molecular Life Sciences, 76, 473-493. https://doi.org/10.1007/s00018-018-2943-4.

Sircana, A., Framarin, L., & Leone, N. (2018). Altered gut microbiota in type 2 diabetes: just a coincidence?. Current Diabetes Report, 18(10), 98. https://doi.org/10.1007/s11892-018-1057-6.

Pathak, P., Xie, C., Nichols, R.G., Ferrell, J.M., Boehme, S., & Krausz, K.W. (2018). Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism. Hepatology, 68(4), 1574-1588. https://doi.org/10.1002/hep.29857.

Heianza, Y., Sun, D., Li, X., Di Donato, J.A., Bray, G.A., & Sacks, F.M. (2018). Gut microbiota metabolites, amino acid metabolites and improve- ments in insulin sensitivity and glucose metabolism: the POUNDS Lost trial. Gut, 68(2), 263-270. https://doi.org/10.1136/gutjnl-2018-316155.

Scheithauer, T. P., Rampanelli, E., Nieuwdorp, M., Vallance, B. A., Verchere, C. B., Van Raalte, D. H., & Herrema, H. (2020). Gut microbiota as a trigger for metabolic inflammation in obesity and type 2 diabetes. Frontiers in Immunology, 2546, 11, 571731. https://doi.org/10.3389/fimmu.2020.571731.

Alexander, C., Swanson, K.S., Fahey, G.C., & Garleb, K.A. (2019). Perspective: physiologic importance of short-chain fatty acids from nondigestible carbohydrate fermentation. Advance Nutrition, 10(4), 576–589. https://doi. org/10.1093/advances/nmz004

Gao, Z. (2009). Butyrate improves insulin sensitivity and increases energy expenditure in mice. Diabetes, 58(7), 1509-1517. https://doi.org/10.2337/db08-1637.

Lin, H.V., Frassetto, A., Kowalik, E.J., Nawrocki, A.R., Lu, M.M., Kosinski, J.R., Hubert, J.A., Szeto, D., Yao, X., & Forrest, G. (2012). Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms. Plos One, 7, e35240. https://doi.org/10.1371/journal.pone.0035240.

Gao, Z., Yin, J., Zhang, J., Ward, R.E., Martin, R.J., Lefevre, M., Cefalu, W.T., & Ye, J. (2009). Butyrate improves insulin sensitivity and increases energy expenditure in mice. Diabetes, 58(7), 1509–1517. https://doi.org/10. 2337/db08-1637

Duncan, S.H., Belenguer, A., Holtrop, G., Johnstone, A.M., Flint, H.J. & Lobley, G.E. (2007). Reduced dietary intake of carbohydrates by obese subjects results in decreased concentrations of butyrate and butyrate-producing bacteria in feces. Applied and Environmental Microbiology, 73, 1073-1078. https://doi.org/10.1128/AEM.02340-06.

Larsen, N., Vogensen, F.K., Van Den Berg, F.W., Nielsen, D.S., Andreasen, A.S., & Pedersen, B.K. (2010). Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. Plos One, 5(2), e9085. https://doi.org/10.1371/journal. pone.0009085.

Qin, J., Li, Y., Cai, Z., Li, S., Zhu, J., & Zhang, F. (2012). A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature, 490(7418), 55–60. https://doi.org/10.1038/nature11450.

Karlsson, F.H., Tremaroli, V., Nookaew, I., Bergström, G., Behre, C.J., & Fagerberg, B. (2013). Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature, 498(7452), 99–103. https://doi.org/10.1038/nature12198.

Yang, G., Wei, J., Liu, P., Zhang, Q., Tian, Y., Hou, G., & Jiang, X. (2021). Role of the gut microbiota in type 2 diabetes and related diseases. Metabolism, 117, 154712. https://doi.org/10.1016/j.metabol.2021.154712.

Zhang, X., Shen, D., Fang, Z., Jie, Z., Qiu, X., Zhang, C., & Ji, L. (2013). Human gut microbiota changes reveal the progression of glucose intolerance. Plos One, 8(8), e71108. https://doi.org/10.1371/journal.pone.0071108.

Wu, H., Tremaroli, V., Schmidt, C., Lundqvist, A., Olsson, L. M., Krämer, M., & Bäckhed, F. (2020). The gut microbiota in prediabetes and diabetes: a population-based cross-sectional study. Cell Metabolism, 32(3), 379-390. https://doi.org/10.1016/j.cmet.2020.06.011.

Lambeth, S. M., Carson, T., Lowe, J., Ramaraj, T., Leff, J. W., Luo, L., & Shah, V. O. (2015). Composition, diversity and abundance of gut microbiome in prediabetes and type 2 diabetes. Journal of Diabetes and Obesity, 2(3), 1-7. https://doi.org/10.15436/2376-0949.15.031.

Zhao, L., Lou, H., Peng, Y., Chen, S., Zhang, Y., & Li, X. (2019). Comprehensive relationships between gut microbiome and faecal metabolome in individuals with type 2 diabetes and its complications. Endocrine, 66, 526-537. https://doi.org/10.1007/s12020-019-02103-8.

Zhong, H., Ren, H., Lu, Y., Fang, C., Hou, G., Yang, Z., & Li, J. (2019). Distinct gut metagenomics and metaproteomics signatures in prediabetics and treatment-naïve type 2 diabetics. EBioMedicine, 47, 373-383. https://doi.org/10.1016/j.ebiom.2019.08.048.

Gaike, A. H., Paul, D., Bhute, S., Dhotre, D. P., Pande, P., Upadhyaya, S., & Shouche, Y. S. (2020). The gut microbial diversity of newly diagnosed diabetics but not of prediabetics is significantly different from that of healthy nondiabetics. Msystems, 5(2), e00578-19. https://doi.org/10.1128/mSystems.00578-19.

Zhang, Z., Tian, T., Chen, Z., Liu, L., Luo, T., & Dai, J. (2021). Characteristics of the gut microbiome in patients with prediabetes and type 2 diabetes. PeerJ, 9, e10952. https://doi.org/10.7717/peerj.10952.

Virieze, A.M., Druesne, A., Van Hylckama Vlieg, J.E., Bloks, V.W., Groen, A.K., Heilig, H.G., Zoetendal, E.G., Stroes, E.S., de Vos, W.M., Hoekstra, J.B., & Nieuwdorp, M. (2012). Transfer of intestinal microbiota from lean donors increases insulin sensiti vity in individuals with metabolic syndrome. Gastroenterology, 143, 913-6.e7. https://doi.org/10.1053/j.gastro.2012.06.031.

Hur, K.Y. (2017). Gut Microbiota and Metabolic Disorders. The Journal of Korean Diabetes, 18(2), 63-70. https://doi.org/10.4093/dmj.2015.39.3.198.

Delzenne, N.M., Neyrinck, A.M., Backhed, F., & Cani, P.D. (2011). Targeting gut microbiota in obesity: effects of prebiotics and probiotics. Nature Reviews Endocrinology, 7, 639-646. https://doi.org/10.1038/nrendo.2011.126.

Simon, M.C., Strassburger, K., Nowotny, B., Kolb, H., Nowotny, P., & Burkart, V. Intake of lactobacillus reuteri improves incretin and insulin secretion in glucose-tolerant humans: a proof of concept. Diabetes Care, 38(10), 1827–1834. https://doi.org/10. 2337/dc14-2690.

Mobini, R., Tremaroli, V., Ståhlman, M., Karlsson, F., Levin, M., & Ljungberg, M. (2017). Metabolic effects of lactobacillus reuteri DSM 17938 in people with type 2 diabetes: a randomized con- trolled trial. Diabetes Obesity and Metabolism, 19(4), 579–589. https:// doi.org/10.1111/dom.12861.

Ruan, Y., Sun, J., He, J., Chen, F., Chen, R., & Chen, H. (2015). Effect of probiotics on glycemic control: a systematic review and meta-analysis of randomized, controlled trials. Plos One, 10(7), e0132121. https://doi.org/10.1371/journal.pone.0132121.

Li, C., Li, X., Han, H., Cui, H., Peng, M., & Wang, G. (2016). Effectof probiotics on metabolic profiles in type 2 diabetes mellitus: a meta-analysis of randomized, controlled trials. Medicine (Baltimore), 95(26), e4088. https://doi.org/10.1097/MD. 0000000000004088.

Samah, S., Ramasamy, K., Lim, S.M., Neoh, C.F. (2016). Probiotics for the management of type 2 diabetes mellitus: a systematic review and meta-analysis. Diabetes Research and Clinical Practice, 118, 172–182. https:// doi.org/10.1016/j.diabres.2016.06.014.

Akbari, V., & Hendijani, F. (2016). Effects of probiotic supplementation in patients with type 2 diabetes: systematic review and meta-analysis. Nutrition Reviews, 74(12), 774–784. https://doi.org/10.1093/njtrit/nuw039.

Yao, K., Zeng, L., He, Q., Wang, W., Lei, J., & Zou, X. (2017). Effect of probiotics on glucose and lipid metabolism in type 2 diabetes mellitus: a meta-analysis of 12 randomized controlled trials. Medical Science Monitor, 23, 3044–3053. https://doi.org/10.12659/MSM.902600.

David, L.A., Maurice, C.F., Carmody, R.N., Gootenberg, D.B., Button, J.E., & Wolfe, B.E., (2014). Diet rapidly and reproducibly alters the human gut microbiome. Nature, 505(7484), 559–563. https://doi.org/10.1038/nature12820.

Houghton, D., Hardy, T., Stewart, C., Errington, L., Day, C.P., & Trenell, M.I. (2018). Systematic review assessing the effectiveness of dietary intervention on gut microbiota in adults with type 2 diabetes. Diabetologia, 61(8), 1700-1711. https://doi.org/10.1007/s00125-018-4632-0.

Zhao, L., Zhang, F., Ding, X., Wu, G., Lam, Y.Y., & Wang, X. (2018). Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes. Science, 359(6380), 1151–1156. https://doi.org/10. 1126/science.aao5774.

Smith, P.M., Howitt, M.R., Panikov, N., Michaud, M., Gallini, C.A., & Bohlooly, Y.M. (2013). The microbial metabolites, short-chain fatty acids, regulate colonic treg cell homeostasis. Science, 341(6145), 569–573. https://doi.org/10.1126/science.1241165.

Li, X., Watanabe, K., & Kimura, I. (2017). Gut microbiota dysbiosis drives and implies novel therapeutic strategies for diabetes mellitus and related metabolic diseases. Frontiers in Immunology, 8, 1882. https://doi.org/10.3389/fimmu.2017.01882

Hansen, C.H., Krych, L., Buschard, K., Metzdorff, S.B., Nellemann, C., & Hansen, L.H. (2014). A maternal gluten-free diet reduces inflammation and diabetes incidence inthe offspring of NOD mice. Diabetes, 63, 2821–2832. https://doi.org/10.2337/db13-1612.

Pereira, M.A., Kartashov, A.I., Ebbeling, C.B., Van Horn, L., Slattery, M.L., & Jacobs, D.R. (2015). Fast-food habits, weight gain, and insulin resistance (the CARDIA study): 15-year prospective analysis. Lancet, 365(9453), 36–42. https://doi.org/10.1016/S0140-6736(04)17663-0.

Han, J.L., & Lin, H.L. (2014). Intestinal microbiota and type 2 diabetes: from mechanism insights to therapeutic perspective. World Journal of Gastroenterology: WJG, 20(47), 17737. https://doi.org/10.3748/wjg.v20.i47.17737.

Birkeland, E., Gharagozlian, S., Birkeland, K.I., Valeur, J., Måge, I., Rud, I., &Aas, AM. Prebiotic effect of inulin-type fructans on faecal microbiota and short-chain fatty acids in type 2 diabetes: a randomised controlled trial. Eur J Nutr. 2020 Oct;59(7):3325-3338. https://doi.org/10.1007/s00394-020-02282-5.

Li, K., Zhang, L., Xue, J., Yang, X., Dong, X., & Sha, L. (2019). Dietary inulin alleviates diverse stages of type 2 diabetes mellitus via anti-inflammation and modulating gut microbiota in db/db mice. Food Function, 10(4), 1915–1927. https://doi.org/10.1039/C8FO02265H.

Morshedi, M., Saghafi-Asl, M., & Hosseinifard, E.S. (2020). The potential therapeutic effects of the gut microbiome manipulation by synbiotic containing- Lactobacillus plantarum on neuropsychological performance of diabetic rats. Journal Translational Medicine, 18(1), 18. https://doi.org/10.1186/s12967-019-02169-y.

Wang, Z., Li, W., Lyu, Z., Yang, L., Wang, S., Wang, P., Song, F., Chen, K., &Huang, Y. (2022). Effects of probiotic/prebiotic/synbiotic supplementation on blood glucose profiles: a systematic review and meta-analysis of randomized controlled trials. Public Health, 210, 149-159. https://doi.org/10.1016/j.puhe.2022.06.012.

Nazzaro, F., Fratianni, F., Nicolaus, B., Poli, A., & Orlando, P. (2012). The prebiotic source influences the growth, biochemical features and survival under simulated gastrointestinal conditions of the probiotic Lactobacillus acidophilus. Anaerobe, 18(3), 280–285. https://doi.org/10.1016/j.anaerobe.2012.03.002.

Mahboobi, S., Rahimi, F., & Jafarnejad, S. (2018). Effects of prebiotic and synbiotic supplementation on glycaemia and lipid profile in type 2 diabetes: a meta-analysis of randomized controlled trials. Advanced Pharmaceutical Bulletin, 8(4), 565–574. https://doi.org/10.15171/apb.2018.065.